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Tropical performance evaluation of malaria tests

Diagnostics - The largest-ever independent, laboratory-based evaluation of rapid diagnostic tests (RDTs) for malaria has shown that not all tests perform equally where they are needed most - in tropical environments.

Testing was performed at the US Centers for Disease Control and Prevention (CDC). Forty one commercially available RDTs went through a blinded laboratory evaluation. Some tests on the market perform exceptionally well in tropical temperatures - detecting even low parasite densities in blood samples - while other tests can detect parasites only at high densities.

The findings will serve as a tool for countries to make informed choices, from the dozens of tests commercially available, on the purchase and use of rapid diagnostics that are best suited to local conditions.

This performance evaluation will also inform procurement and prioritisation for diagnostic test entry into WHO Prequalification Diagnostics Programme and WHO Procurement Schemes. Donor agencies also regularly refer to WHO recommendations on diagnostics when making their own purchases.

"This is an important first step in establishing a broader system of diagnostics surveillance and quality assurance to ensure sound and accurate diagnosis of malaria in poor and remote settings," said Dr Robert Ridley, Director of TDR.

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