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Biosensor makes drug detection crystal clear

Scientists have developed a new class of disposable, microplate-based optical biosensor capable of detecting protein-DNA interactions.

Based on the properties of photonic crystals, the biosensors are suitable for the rapid identification of various drugs that affect protein-nucleic acid and protein-protein interactions.

"First, we selectively attach a biomolecule, such as DNA, to the bottom of each well. Then we see how that biomolecule interacts with other molecules, including drugs," said Professor Brian Cunningham of the University of Illinois in the US.

By examining the light reflected from the photonic crystal, the researchers can tell when molecules are added to, or removed from, the crystal surface. The measurement technique is ideal, say the team, in a high-throughput screening set-up to rapidly identify molecules and compounds that prevent DNA-protein binding.

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